HIF1A-AS2 INDUCES OSIMERTINIB RESISTANCE IN LUNG ADENOCARCINOMA PATIENTS BY REGULATING THE MIR-146B-5P/IL-6/STAT3 AXIS

HIF1A-AS2 induces osimertinib resistance in lung adenocarcinoma patients by regulating the miR-146b-5p/IL-6/STAT3 axis

Although epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) Inline - Wheels Court show efficacy in lung adenocarcinoma (LUAD) patients, TKI resistance inevitably develops, limiting long-term results.Thus, there is an urgent need to address drug resistance in LUAD.Long non-coding RNA (lncRNA) HIF1A-AS2 could be a critical mediator in

read more



A Study of Failure Events in Drinking Water Systems as a Basis for Comparison and Evaluation of the Efficacy of Potable Reuse Schemes

Potable reuse is implemented in several countries around the world to augment strained water supplies.This article presents a public health perspective on potable reuse by comparing the critical infrastructure and institutional capacity characteristics of two well-established potable reuse schemes Ball - Umpire - Shoes with conventional drinking wa

read more

Large-Deformation Failure Mechanism of Coal-Feeder Chamber and Construction of Wall-Mounted Coal Bunker in Underground Coal Mine with Soft, Swelling Floor Rocks

In traditional vertical coal bunker systems, a coal-feeder chamber (CFC) must bear the whole weight of the bunker.However, maintenance of CFCs within soft, swelling floor rock is a challenge faced in underground coal mines.Floor-heave control is a complex problem and is still not well-solved.Moreover, there is no report on the construction of bunke

read more